Assisted Reproductive Technology(ART)

Intracytoplasmic Morphologically Selected Sperm Injection (IMSI)

Intracytoplasmic Morphologically Selected Sperm Injection basics
  • The form of the sperm is a very relevant prediction factor for fertilization in natural pregnancy, IUI, IVF, ICSI.
  • Sperm mutation through large vacuoles within the sperms act as factors that decrease fertilization by ICSI.
  • An increase in pregnancy rate is achieved by selecting normal sperms from sperms with large vacuoles through a zoomed in screen.

Candidates for IMSI technique
  • IVF-ET patients from Testicular sperm extraction(TESE)
  • Cases with Teratozoospermia (normal sperm below 4%, globozoospermia, pin-head sperm in strict morphologically sperm examination)
  • Recurrent failure cases of fertilization and implantation
  • Cases of recurrent miscarriage

IMSI methods and advantages
  • Fertilization and embryodevelopment can be enhanced By observing the sperms through a 10,000X magnified screen during ICSI and screening for abnormalities
  • Implantation and pregnancy rate can be increased through a higheer normal embryo ratio by selecting more normal sperms for Teratozoospermia or TESE cases.
  • IMSI can minimize chromosomal anomaly or embryo developmental failure from recurrent pregnancy failures and fetal loss.